WebNov 20, 2003 · This account examines double asymmetric induction from theoretical and practical viewpoints. In the context of four major organic reactions-the aldol, Diels-Alder, catalytic hydrogenation, and ... Asymmetric induction is a key element in asymmetric synthesis . Asymmetric induction was introduced by Hermann Emil Fischer based on his work on carbohydrates. [2] Several types of induction exist. Internal asymmetric induction makes use of a chiral center bound to the reactive center through … See more In stereochemistry, asymmetric induction (also enantioinduction) describes the preferential formation in a chemical reaction of one enantiomer or diastereoisomer over the other as a result of the influence of a See more It has been observed that the stereoelectronic environment at the β-carbon of can also direct asymmetric induction. A number of predictive models have evolved over the years to define the stereoselectivity of such reactions. Chelation model See more Chiral acyclic alkenes also show diastereoselectivity upon reactions such as epoxidation and enolate alkylation. The substituents around … See more Cyclic molecules often exist in much more rigid conformations than their linear counterparts. Even very large macrocycles like See more Several models exist to describe chiral induction at carbonyl carbons during nucleophilic additions. These models are based on a … See more If the substrate has both an α- and β-stereocenter, the Felkin–Anh rule (1,2-induction) and the Evans model (1,3-induction) should considered at the same time. If these two … See more Asymmetric induction by the molecular framework of an acyclic substrate is the idea that asymmetric steric and electronic properties of a … See more

The development of highly active acyclic chiral hydrazides for ...

WebDouble asymmetric induction as a mechanistic probe indicates that, for the conjugate addition of (R)- and (S)-lithium N-benzyl-N-α-methylbenzylamide to (S)-3′-phenylprop-2′-enoyl-4-benzyloxazolidinone, the reactive conformation of the N-acyl oxazolidinone is the anti-s-cis form, facilitating the asymmetric s WebNov 15, 2013 · A double asymmetric induction in the synthesis of α-aminophosphonic acids is described. It involves the nucleophilic addition of anions of enantiomeric … boundary markers

Origins of the Double Asymmetric Induction on Proline …

WebNew ligands give improved double diastereoselection in asymmetric dihydroxylation (AD) of chiral olefins. WebJul 1, 2004 · A multiple asymmetric induction synthesis was applied to increase the stereoselectivity of the phosphaaldol reaction. The double stereoselectivity was achieved in the reaction of chiral di(1R,2S ... WebThe strategy of double asymmetric induction was utilized in Baylis–Hillman reaction for the first time by the coupling of chiral aldehydes with chiral acrylate (1,2:5,6-di-O … gucci thong sandals men\u0027s