Biologically relevant motifs
WebJan 11, 2024 · We show that LncLOOM is capable of identifying specific, biologically relevant motifs which are conserved throughout vertebrates and beyond in lncRNAs … WebSep 10, 2014 · Biologically relevant linear motifs often exhibit a statistical significance that lies in or near the twilight zone (i.e. where there is a non-negligible probability to observe a random motif) . This difficulty begs for a better understanding and characterization of motif statistical significance [2] , [18] , and calls for alternative approaches.
Biologically relevant motifs
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WebMay 14, 2024 · Identification of biologically relevant motifs in proteins is a long-standing problem in bioinformatics, especially when considering distantly related proteins where sequence analysis alone becomes increasingly difficult. Here we present a novel approach to identify such motifs in protein three-dimensional structures without depending on se- WebAug 22, 2008 · Having chosen biologically relevant motif MHG p-value thresholds, we next compared the KMM motifs found by our motif finder for the TF-condition sets with the motifs published by MacIsaac et al. . For each TF-condition set, we allowed the motif finder to output up to five unique motifs. Only those that passed their sets' bin threshold were ...
WebMay 14, 2024 · Here we present a novel approach to identify such motifs in protein three-dimensional structures without depending on sequence alignment by representing … WebMar 1, 2024 · Thus, such biologically relevant portions of chemical space may only be accessible by exploiting features encoded and subsequently passed-on through the incorporation of structural motifs generated by secondary metabolite biosynthesising proteins, which themselves share evolutionary conserved structural features. 13 This …
WebMay 11, 2004 · Whether we can define modules in a stringent biologically relevant fashion is not just important for our understanding of the organization of biological systems. Many authors have conjectured that if modules are real they may also be more likely to contain proteins that are essential to viability. ... In the case of the 5' motifs, the statistic ... WebSep 27, 2024 · Introduction. Biopolymers, such as DNA and protein, perform varying functions based on their primary sequence. Short, repeated sequences, or “motifs” represent functional units within biopolymers that …
WebThis can be achieved by using macrocyclization to constrain peptides into their unique and bioactive conformations. Macrocyclic-based designs of biologically relevant peptides may be informed by the patterns of hydrogen bonding observed in X-ray crystal structures. Covalent surrogates of hydrogen bonds reduce entropy by destabilizing unfolded ...
WebJan 13, 2024 · Overall, these findings suggest that shortening the upstream region increases the signal-to-noise ratio to detect biologically relevant motifs and, at the same time, reduces the occurrence of low complexity AT-rich motifs. In Figure 3, we illustrate a clear example of this observation. Indeed, with both oligo and dyad analysis, the statistical ... chingford rentWebAn important aspect is that under normal cellular concentrations, biologically relevant motifs will generally outcompete lower affinity off-target instances 38 (the implications for motif definitions based purely on … chingford rent houseWebSep 6, 2012 · This highlights a caveat in predicting expression from motifs; while we can identify biologically relevant motifs, this type of analysis only suggests a subset of factors that likely bind to a ... grange train stationWebMar 16, 2024 · Fig. 5: Scope of diarylation of biologically relevant motif coupled alkynes and synthetic applications. All reactions are carried out on a 0.2 mmol scale. All the compounds are isolated as a ... grange train timetableWebFeb 7, 2008 · We conclude that many biologically relevant motifs appear heterogeneously distributed in the promoter region of genes, and therefore, that non-uniformity is a good indicator of biological relevance and can be used to complement over-representation tests commonly used. In this article we present the results obtained for the S. cerevisiae data … grange travel coach hire ltdWebJan 11, 2024 · We show that LncLOOM is capable of identifying specific, biologically relevant motifs which are conserved throughout vertebrates and beyond in lncRNAs … chingford retail parkWebInteractions between protomers are illustrated on the basis of oligomeric structures of each AAA+ subgroup. The possible role of conserved motifs in the nucleotide binding pocket … chingford reservoir